The brain is very plastic. Which is why often the first sign of a brain tumor (including in people working mentally intensive jobs like PhD student) is a seizure, or paralysis, or deafness. All signs that plasticity in some part of the brain has reached its limit.
i don't follow from this why plasticity reaching its limit in some part of the brain manifests overtly as seizure/paralysis/deafness. those sound more like existing pathways being disrupted, as opposed to the ability to form new pathways being inhibited?