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Meta comment: it seems like you can only voice a particular direction on the politic topic of immigration enforcement on this thread without getting downvoted. The opinion is obvious because everyone automatically jumps to malice as opposed to incompetence as the prevailing theory for the article's claim.

I had a condescending response from a HN mod the other day telling me that HN isn't all that left wing, just a 'slight skew'. Well OK buddy, exhibit A, read through the diversity of opinions that aren't flagged in this thread. I'd go as far to say that HN is basically like Reddit, except more of you happen to have computer science degrees.

And that's fine, it is what it is, but let's not pretend this website doesn't have a heavy bias in a particular direction.


From what I know, politologists are analyzing the situation in US from a perspective of "mid intensity civil war".

So what you're writing is aligned with tactics you'd expect...?


immigration enforcement has existed for as long as HN has existed, yet there was never this much attention paid to it. Even under the same president during the previous term.

So simply supporting or opposing "immigration enforcement" must not be it. Something must be different about this situation. I encourage you to dig deeper, or actually ask those who disagree with you, what that difference might be. And beware of falling victim to the easy dismissal of 'more people are less rational and/or less informed than before', a variant of 'this person who doesn't agree with me must be less rational and/or less informed than me'.


Here's what's actually different:

- This admin is deporting less than Obama was during his first year in office despite promises to the contrary,

- There is now organized harassment and resistance stopping federal agents from removing illegals that are also criminals from our country.

Ironically, you need to take your own advice.

One side is crazier, and it's not mine.


LLMs have already proven themselves to be economically valuable. At a bare minimum, they can help people develop most low-mid level software considerably faster, at a good enough quality.

They also have proven themselves in other white collar knowledge endeavors as well, as valuable tools that augment human economic output. Marketers can make more copy material, any office worker can improve the quality of their email communications, etc. Easy.

What are humanoids doing exactly? What can they do, that actually makes sense and provides positive economic impact over existing alternatives? Not clear to me.


Ok but can we get into the nuts and bolts of what we actually want these robots to do?

Because every time I think of something, either an existing industrial setup can or will do it better, or a special-purpose device will beat it.

So general intelligence + general form factor (humanoid) sounds great, if feasible. But what will it do exactly? And then let's do a reality check on said application.


The hardware is great and can definitely scale. That's why as a caveat I think teleoperation is a good general purpose application cluster for these.

But I really struggle to come up with any other economically viable short-term use cases, even with great hardware...


Interesting indeed. Does such a finding suggest any worthwhile easy-to-try 'treatments' that may help alleviate symptoms?

I don't know much about the biochemistry here, I assume this is not something like GABA that can be directly supplemented. But maybe there are precursor nutritional and supplemental substances that can help these people upregulate how much of the glutamate molecule in question the body can produce.


There isn't enough information to start doing that. Consider: UV exposure results in sunburn, cellular damage, and increased skin pigmentation. We have medication that reduces skin pigmentation. Should we give it to people who experience chronic sunburn?


The third paragraph:

> Now, a new study in The American Journal of Psychiatry has found that brains of autistic people have fewer of a specific kind of receptor for glutamate, the most common excitatory neurotransmitter in the brain. The reduced availability of these receptors may be associated with various characteristics linked to autism.

Reduce receptors. This might suggest a _developmental_ or genetic link. Think of this more like "height" or a particular "facial feature" of a person.


God, why are so many people commenting out of their depth today.

> Reduce receptors. This might suggest a _developmental_ or genetic link. Think of this more like "height" or a particular "facial feature" of a person.

No. This isn't how it works at all. Receptor counts are extremely plastic, able to change within a weeks and in some cases hours. This is how you get drug tolerance.


Sure, but they're also 15% lower in people with autism, and shown with a 60-90% heritability.

Supplimentation would not rewrite SHANK3.

You can go to the dentist and get your teeth aligned, but there's a very good chance your children have similar issues.


Unless you can get the blastocyst and fetus to take supplements, any treatment would be attempting to undo the effects that have already taken place.

For now, your best options are ESDM, occupational therapy, modified CBT, ABA, or neurofeedback, depending on your circumstances and presentation. Except for neurofeedback, these are behavioral approaches, so the architectural and neural activity variations aren't directly addressed.


Receptors quite readily remodel in response to external factors. It is one of the things antidepressants do.

To me it's kind of the biggest red flag here, if it's really about receptors then autism should be far more plastic than it is currently defined to be (which is kind of silly since at the moment any sign of plasticity puts you outside one of the hard criteria for an autism diagnosis - so almost definitionally, it can't be the answer).


A lot of people in the corresponding Reddit threads claim that NAC (N-Acetyl Cysteine) might help.


The paper is concerned mainly with one of several glutamate receptor subtypes.


Meta comment - what a weird comment to downvote. I am expressing curiosity in good faith after reading the article, with a fairly logical follow up. What is the point of commenting in this community if it's primarily cynicism and negativity?


Commenting about voting isn't allowed by the HN guidelines. A link to the guidelines is available at the bottom of the page.


No, "AI" is software, and software is a tool, and tools aren't people that should pay taxes.

You wouldn't charge your CNC Machine taxes for the productive labor it produces that could have otherwise been done by a dozen blacksmiths.

By all means have corporate and sales taxes pertaining to the owner of said tools though. Even as a right-leaning individual, it's become pretty clear to me that corporations pay too low in taxes compared to the broad 'middle class'. Corporate tax cuts don't help the common man. An extra few hundred in their pockets each month certainly would though.


Costco doesn't seem to be like a monopoly, broadly speaking they compete with many grocery stores and bulk food outlets. That being said they often have solid inventory, and the samples used to be a nice touch until all my local locations got way too crowded.


Who else competes in that specific market though? Sam's Club and Smart-and-Final are the two I can think of, and it's been a while since I've seen either one of those. Oh, and actual restaurant supply stores, but those are different, imo. Costco's not directly competing with Safeway, for example, as they are different parts of the market.


Can you provide some examples of monopolies for context in this discussion?


They seem decent enough. I barely play games these days, so I don't fully understand the value they add. Just seems like a convenient app store that lets me port my collection across different computers.


That convenience is everything. Doing it well, and not falling into the trap of putting profit (too far) above users is the challenge that is too hard for other players (except maybe GoG) to get right. It's like WiFi. You go somewhere, connect, it works, and then you don't think about it unless it's surprisingly fast, or there are problems with it. Everyone else's offerings on this space just feel janky and liable to take your money for some reason. Steam, for the majority of its users "just works". That's not to say there are zero buys with the software and that nobody has valid complaints about it, but just that in general it's great.


It's still facing the headwind that a lot of people still don't believe that Steam can give you a lean-back experience which is fun like a game console. Some people still think PC games all have sweaty keyboard and mouse control schemes and those crappy huge joysticks from the 1990s that were always falling apart and had to be recalibrated every few minutes -- and that's what is keeping the PS5 alive.


I loved Pebble back in the day, and Eric is a great guy and friend to entrepreneurs trying to build cool things.

I do wonder how a modern revival of Pebble will compete from a product perspective within the current landscape. Obviously there's the high-end Apple Watches, but there's also incredibly cheap and long battery life products from China that you can see on Aliexpress and similar. Fitness tracking is another related niche that seems oversaturated, unless you do something really unique in biometrics sensing.

So it seems like a hard market to get back into, curious where they take things.


I used a super-cheap Chinese smartwatch (Amazfit Bip S) for years and recently switched to the Pebble. The Bip's battery lasted forever and it did check a lot of feature boxes, but overall it was clunky to use and not in any way hackable.

I switched to a Pebble 2 Duo recently and while the features are comparable on paper (multi-week battery life, reflective display, basic health tracking, etc.), everything is just nicer on the Pebble. The software is thoughtful and fun and there are tons of third-party apps, so it can do all kinds of things the Bip could never do.

There really isn't a huge market for this kind of thing; most people, including nerds, want a watch with a brightly colored screen and tons of health metrics and service integrations. I imagine Pebble will stay a boutique brand this time around.


If there is market for long lasting watch, I think it is if it looks like a traditional round watch. Or if it can work as outdoors watch. Garmin is moving from transflective to AMOLED for better colors, and there might be spot for rugged, long-lasting, cheap watch.


I think Eric has more-or-less implied that they will probably make a Pebble Time Round successor (no doubt with worthwhile battery life this time, given how much more the Duo is)


They sold the whole production run of Pebble 2 Duos, and they are keeping the company small to be sustainable this time. I think they have a chance.

The Pebble software is second to none in nailing the basics. I'll definitely continue to choose Pebble over no-name brands on AliExpress.


> They sold the whole production run of Pebble 2 Duos,

They actually sold more than the whole run; I ordered one, and recently got an email informing me that they don't actually have the parts to fulfill the order.


The key value of Pebble to me was its incredible C SDK that made it super easy to write custom apps for it. I remember way back I got full turn-by-turn navigation working on it.


One thing I don't understand:

> Pebble 2 Duo is sold out! We are not making more. If you want a Pebble, I recommend pre-ordering a Pebble Time 2 soon.

Is this supposed to be a collector's item? I'm not sure I'd want to invest in an ecosystem where damaging the device means I'm out or stuck waiting in line for replacement - with no guarantee the new device will be similar enough.


Pebble 2 Duo were reusing the existing stock of Pebble 2 housings and displays. This model was intended as a limited run from the beginning.

Pebble Time 2 are designed from scratch and expected to be still available after the pre-order batches have been shipped out.


Thanks for the clarification.

I just hope supporting this limited run model will not consume too much resources.


I think they have a very clear niche: nerdy techies (like me).

The question is indeed if it's a big enough market to carry to the company. I hope so.


The Pebble brand name definitely helps them break back into the market. Even some of my non-techy friends recognize the name.


except for the apps for those cheap watches, all your data is uploaded to servers somewhere all the time I assume.


I heard that no one likes him because he has no morals, but that's just what i heard


OK but surely it can do this given your instructional prompting. I get they have a default behavior, which perhaps isn't your (or my) preference.


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