Very dumb question, but how exactly does gene therapy work in vivo? Don't you have to modify every cell (or affected type of cell) with a new copy of the DNA? How does that actually.... happen?
> Don't you have to modify every cell (or affected type of cell) with a new copy of the DNA?
It depends on the specific disorder that’s being treated. For some of them, targeting a fraction of the affected cells is enough to get the desired effect.
If the affected protein is actively causing problems, then you'd need to get most of the cells. But if it's just inert and not doing its job then you only need to get enough cells to get the production of the right version up to a somewhat functional level.
It's like trying to persuade enough people (cell) to change their mind so a social revolution takes place (cure). The argument (gene vector) must be very popular.
I strongly also think we're going to have a social network for humans-only (and one for AI-only, and one for humans + AI)
have you looked into world.org? They're scanning eyes and giving robust human identities. Before immediately dismissing, I'd check out the video -- https://www.youtube.com/watch?v=SXnwoMxKHV8
I think atproto + worldid can one day be very interesting
What about the current DeFi framework makes it impossible to address?
Imo smart contract engineering has much more in common with firmware, hardware, etc. than the mindset a typical React/web2 engineer might have (i.e. try things and iterate). I think that point is not talked about enough.
To be fair, you do have to start with over-collateralized loans before you can get under/no collateral loans with plenty of projects trying to do the latter. That's how lending itself started (https://www.provenir.com/resources/collateral/history-of-len...).
But I agree that if it's always overcollateralized then there is obviously much less utility created (though definitely some - similar to how you can get a loan against your home).
The project mentioned, Goldfinch, has already distributed 4.5M in uncollateralized loans to emerging markets using DeFi rails and liquidity already (https://medium.com/goldfinch-fi/goldfinch-raises-11m-from-an...). My 2c is that it's a sign of what's to come.
About Goldfinch: Perhaps I've seen too many movies, but the "backers" look like the guys that will vouch for you to get the loan and break you knees in case you forgot to pay it back.
> To be fair, you do have to start with over-collateralized loans before you can get under/no collateral loans with plenty of projects trying to do the latter.
Yeah but also the collateral always has to be cryptocurrency right?
Yes for the most part it is. One reason being that it's just a lot easier to code and cleaner when everything is on-chain and tracked the same way.
But that's starting to change (https://centrifuge.io/) - still a long way to go ofc. I also know people who have done non-crypto collateral or just completely unsecured lending, but it does involve trust that is off-chain (legal contract, know the person, etc). I think that's a fine stepping stone (and may end up being necessary) as people figure out how to do everything on-chain and in decentralized ways (ex. using on-chain reputation)
> "How should I choose what to do? Well, how had I chosen what to work on in the past? I wrote an essay for myself to answer that question, and I was surprised how long and messy the answer turned out to be. If this surprised me, who'd lived it, then I thought perhaps it would be interesting to other people, and encouraging to those with similarly messy lives. So I wrote a more detailed version for others to read, and this is the last sentence of it."
I loved the ending. The essay was primarily for him. It seems that some of the best writing, similarly to the best products, is when you yourself are the recipient.
>I actually buy the reasoning behind it - but putting out a corporate speak like this instead of trying to emotionally relate to upset users? Smh
Their reasoning makes no sense. If someone isn't buying on margin, who are they protecting exactly? Citadel and Melvin Capital, that's who. The funds weren't "protected", were they?
Just like "we are bullshitting but look at our smile". And there is a way to present a facet of the reality while clouding another one so I'm not saying their message is a complete lie, it's just taken from a controlled perspective.
TSLA and Comma.Ai aren't only ones. Ghost (https://driveghost.com/) is funded by top VCs (incubated at sutter hill ventures, same firm that incubated Snowflake) with a highly technical second time founder in John Hayes (first company is the public company Pure Storage).
They're taking the same bet (i.e. CV + ML advances on a large and high quality enough data set are enough). After listening to Hoetz on podcasts, I wouldn't underestimate this approach. People trying orthogonal technical approaches win surprisingly often.
