I got pretty good with InDesign during high school, where I took Graphic Communications at our vo-tech. It really is an awesome tool for getting print ready. We used it in conjunction with an actual printing press.

If I had to do it now I would use LaTeX though. For me, open always trumps proprietary when available, and because of their proprietary sort of walled garden nature, Adobe is not a company I would like to support.

Open source is cool and all. But I'm not exaggerating when I say that doing the same thing in LaTeX would take years longer than doing it in InDesign, assuming the output of both is close enough to what I'm trying to achieve. So those years count toward something for me.

I used LaTeX a few times in anger while at the university.

Afterwards in the outside world, Office became the rule as I never needed to type mathematics again.

When we did a technical documentation project, DITA and Docbook were used instead, with WYSISWYG editors like oXygen.