It's for accounting improprieties, not a drug hustle. The fine is proportional to the crime. Even if we charged $800 million for this, would we charge $800 million for them not having a handicapped parking space at one of their offices?
Comparing to overall profits is counterproductive and dishonest. The punishment should fit the crime.
Comparing to overall profits is necessary when the discussion is about whether the penalty financially screws Monsanto's shareholders over. Nowhere in the parent thread is there a discussion going on about whether this is an appropriate penalty, just whether or not it "screws" Monsanto - in the context of their 2015 earnings statement, it's obviously not.
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[1]: http://www.monsanto.com/investors/documents/2015/2015.10.06_... - "Gross Profits: $8,182 M"
edit: accidentally a word