Hardware: Dell Vista box with 24" and 22" monitor and Mac Mini with 22" monitor with single wireless Logitech Wave keyboard/mouse via Synergy. Dell Mini 9 netbook with Ubuntu Remix also hooked to Synergy when its at my desk.
Software: use Window's box for dev work - Notepad++ for editing, FF/Chrome for browser, and Mac for communications - Adium for IM (AIM and internal Jabber) and Colloquy for irc (wmassdevs on freenode) and FF for gmail/google apps/co-op/basecamp/etc.
If I had more desk space I'd have more monitors. I'm moving soon and may end up either attaching monitor arms to the walls or building a shelf for the second set of monitors.
[EDIT]
Here is an older picture of the setup:
http://imgur.com/iAqED.jpg
[/EDIT]
Software: use Window's box for dev work - Notepad++ for editing, FF/Chrome for browser, and Mac for communications - Adium for IM (AIM and internal Jabber) and Colloquy for irc (wmassdevs on freenode) and FF for gmail/google apps/co-op/basecamp/etc.
If I had more desk space I'd have more monitors. I'm moving soon and may end up either attaching monitor arms to the walls or building a shelf for the second set of monitors.