I use Safari, which doesn't have profile handling at all. The web should not rely on clumsy browser hacks. Chrome profiles are way too coarse-grained — all the settings and state (history, bookmarks, etc.) are separate. It also interacts badly with everything else on a computer. If I click on a Slack link to a Google document, then nothing knows which Chrome window to open it in.

Google's mistake was the account switcher. Supporting multiple accounts is fine, but pretending they support concurrent logins is nonsensical.

But I have no choice to use multipel Google accounts, since my company uses Google Apps or G-Suite or Google For Work or whatever it is called today, and I'm consulting for a third company that also does this.