That means the transponder became non-viable at that point. Any sort of in-air catastrophe could have caused that, including onboard fire.
Redundant airplane systems protect against component failure, but they tend to still be near each other. For example, if an AA gun were to tag the plane in the right place it could easily take out power to both a primary and backup.
It really doesn't look like a mid-air explosion. It was either a massive spontaneous fire for some reason (assuming the burning thing in the social media post was the plane) or it got shot down.
That doesn't mean it exploded mid-air. If it exploded mid-air where the FlightRadar24 data end, the debris field would be in the direction of the flight and spread wide. Debris field is in the opposite direction and elsewhere though.
https://www.youtube.com/watch?v=S_iizkgIOfU