UNR844-Cl claims to restore flexibility to the aging lens by breaking the disulfide bonds that form between proteins in the lens. It's a really simple molecule too, composed of common supplements(lipoic acid and choline), so it looks like the risk is fairly low.
I've been following this drug's development process since back when it was named EV06.
Currently people with presbyopia who get laser eye surgery have one eye corrected for looking at nearby objects and the other for those which are far away - this works, but is not ideal.
With UNR844 one could potentially have the same typeof correction in both eyes.
I was just listening to some techniques on YouTube on how to fix presbyopia by switching to older prescriptions from current prescriptions to bring back the elasticity. Apparently focusing on reading or a computer screen too much can create the lens from returning to it's original condition/state as it remains locked/seized up. Might be bullshit but these eye drops would be amazing. I wonder if this is what David Sinclair was talking about when he said they will be able to fix bad vision soon.
I was confused at first because your link is about a different approach, using drugs that temporarily constrict the pupil. The drug that fixes the lens is in human trials too, and would also just be an eye drop. Here's an article:
UNR844-Cl claims to restore flexibility to the aging lens by breaking the disulfide bonds that form between proteins in the lens. It's a really simple molecule too, composed of common supplements(lipoic acid and choline), so it looks like the risk is fairly low.