I'd guess that user oedoedxef is referring to running a customer-facing business (a diner, an auto repair shop, or whatever) out of a primary residence, whether that means living in a commercially-zoned property or doing commerce in a residentially-zoned property or perhaps eliminating the distinction entirely.
Why is it strange? Why should us software developers be allowed to work from home, but others who need a livelihood and provide valuable services to society should not be allowed to produce goods from home?
After all, dentists and tailors see clients in their homes, and people who sell t-shirts online often manufacture and ship the goods from their home.