The vaccines appear to be plenty effective enough to stop the spread, if enough people get them.
We don't have great information about the variants, but the big improvements in Israel and England are encouraging, even with vaccination still ongoing.
> Should reinfection prove commonplace, and barring a highly effective vaccine delivered to most of the world's population, SARS-CoV-2 will likely become endemic.
The thing is, we don't know if reinfection will prove commonplace. We don't know how long immunity will last given a two-shot regimen—though the strong immune response that people are having on the second shot might be cause for hope. We don't know how the virus will mutate on it's point/spike, the main infection vector that the RNA vax target. We just don't know.
Research is emerging, time will tell. In the meantime, it's fear mongering.
Well I will get the vaccine as soon as I can get it (which is not very soon, sadly). I'm not anti-vax, but the last few weeks the news has been all about "Don't be surprised if people still get COVID after being vaccinated". Like here: https://news.ycombinator.com/item?id=26522853
With that in mind I don't think eradication will be achievable. It only takes one person with a resistant mutation. I think we can hope to bring it under control. But not eradicate it.
What does 'control' mean? In humans, if a small number of people are sick and you know who they are, you can eradicate the infection with isolation (it would only take a couple months).
That it infects various animals may make that unworkable, and the difficulty in vaccinating a large percentage of people globally is another problem.
But the effectiveness of the vaccines against the current variants does not appear to be a problem, high levels of vaccination will slow the spread of the virus dramatically in those populations, to the point where it barely exists (compare to polio, which is still endemic in some places around the world).
As far as zoonosis (animal-transmitted human diseases) go...
Rabies infects a lot of animals, but many places of the world are now effectively rabies-free thanks to smart inoculation of foxes etc. with baits.
We had last proven rabies case in the wild in 2002. (The Czech Republic, a landlocked continental country, not an isolated island.)
You can still fall to rabies contracted from bats if extremely unlucky, but compared to countries like India where the disease still runs rampant, rabies is a solved problem in most of Europe.
Maybe there will be a similar way to inoculate the wild mustelids against Covid one day. To be honest, human antivaxxers strike me as a bigger problem than random mink. I don't meet many mink on a regular day, but people with their masks halfway down are all too common.
We don't have great information about the variants, but the big improvements in Israel and England are encouraging, even with vaccination still ongoing.