Naltrexone metabolizes into methylnaltrexone which lasts longer in the blood and has stronger but slightly different binding profiles than its parent. Is the response from LDN the result of naltrexone, its metabolites or both?
I ask because I'm genuinely curious, I'm ignorant of its use for this condition.
I’ve read at these doses it lasts < 4 hrs but I don’t know the mechanism. It is usually taken at night an hour before going to bed and the post inhibition reaction can be felt the same night during sleep so it must be a matter of hours.
I ask because I'm genuinely curious, I'm ignorant of its use for this condition.