Other comments have proposed that depression may have multiple underlying causes, and thus may require different treatments.
I'm curious about the other direction of thinking. What do SSRIs, psychedelics, CBT, and TMS all have in common? Suppose that there is one common cause, or one at least one cause that applies to 90% of cases. And it's treated by all these seemingly disparate methods.
That's what tickles my curiosity the most, as it begs a more fundamental question about the functioning of the brain.
Maybe the author's theory is correct: brain signals between certain regions are going the "wrong" way in depressed patients. That would imply that SSRIs are causing the same shift. God, I would love if the authors tested that. And then we can finally dig into why SSRIs work (we don't current know). If they're causing shifts in brain activity flow, then we can find out how. And from there maybe we can treat other mental diseases with better pharmacological or TMS solutions. Are things like schizophrenia arising from a similar bad pathing of information around the brain?
Psychedelics is also a weird one. People have proposed many theories as to their mode of operation for treating depression. But now I wonder, based on this research, if the key factor was just the disassociation from one's body and altering of senses. The other effects like connecting disparate thoughts, forming more brain connections, ego death, etc may not be related at all. That could lead the way to more targeted drugs.
Really cool stuff. If if pans out, of course. But unlike other theories of depression, at least this one is easy to test.
If you consider that CBT scratches a need for deep socialization, they all basically act on serotonin in different ways. I don’t buy the oversimplified “depression is when your brain doesn’t make enough serotonin” model but it does seem there is a strong connection.
Maybe there is some kind of local optimum your serotonin-mediated pathways can get stuck in and need help getting out of. In fact, this (generalized outside of just serotonin) is something I do buy as a basis for depression: your brain enters some local optima or learns some poor but good-enough coping mechanisms that keep you going but prevent you from fixing underlying issues (whether it be due to maladaptive behavior, framing or interpreting things negatively, low self esteem leading to poor social performance and consequently lower self esteem). That’s also kinda what CBT is about addressing
My understanding of SSRIs is that most of them slow/lower brain activity in some way, so with no specific directionality or acting on specific parts of the brain.
My mental image of it is keeping a classroom under control by stopping every kid from talking to their neighbors.
I'm curious about the other direction of thinking. What do SSRIs, psychedelics, CBT, and TMS all have in common? Suppose that there is one common cause, or one at least one cause that applies to 90% of cases. And it's treated by all these seemingly disparate methods.
That's what tickles my curiosity the most, as it begs a more fundamental question about the functioning of the brain.
Maybe the author's theory is correct: brain signals between certain regions are going the "wrong" way in depressed patients. That would imply that SSRIs are causing the same shift. God, I would love if the authors tested that. And then we can finally dig into why SSRIs work (we don't current know). If they're causing shifts in brain activity flow, then we can find out how. And from there maybe we can treat other mental diseases with better pharmacological or TMS solutions. Are things like schizophrenia arising from a similar bad pathing of information around the brain?
Psychedelics is also a weird one. People have proposed many theories as to their mode of operation for treating depression. But now I wonder, based on this research, if the key factor was just the disassociation from one's body and altering of senses. The other effects like connecting disparate thoughts, forming more brain connections, ego death, etc may not be related at all. That could lead the way to more targeted drugs.
Really cool stuff. If if pans out, of course. But unlike other theories of depression, at least this one is easy to test.