I can see it for programmers. Here you can use industry standard python libraries (shapely, geopandas etc.). Nobody really wants to learn PyQGIS (the python interface for qgis). So while qgis is much more full featured for "desktop" gis (designed to compete with esri arcgis) i can see the use case here for people who want to build their own extensions and port code from this to other python projects more easily.
I see a few advantages. For my work in particular, I have to rely on creating desk study reports via exporting PDFs from QGIS - this depends on export DPI, page size etc. Following that I have to pull those plans into e.g. Word and it's a messy system.
A python notebook would be a nice way of generating reports of GIS data in an interactive way without being forced to use pages, PDFs, and embedded image files.
Where I work, I can't give anything is not a word document to anybody else in the company. A python notebook might help at creating the figures for example, but I can already do that with QGIS layouts.
If the working environment allows for checking/reviewing within the notebook, I guess this could help automatise things.