You might look at ZorinOS or Linux Mint. Mint is very easy to use, I was able to get my elderly mother to use it. It has a software store and built in automatic backups.

Zorin has some built in features to support Windows software pretty easily I understand, but I'm not sure if that's through wine or a VM or what.

You can test them out in your browser thru the website below and see if it fits what you're looking for.

https://distrosea.com/