This statement makes no sense. Besides the fact that literally everything works by manipulating your brain, no one has ever measured a quantum of pleasure, so it can't be “added” to your brain like a unit of flour.
Actually, his explanation is basically how addiction ends up working on the brain. Smoking becomes the new normal, so not smoking makes you go to an extremely bad mood.
This is where the whole "cold turkey" thing comes from and why quitting is so difficult for so many people
